| Similar to: | Similac® 360 Total Care |
Enfamil Optimum (Enspire) Infant Formula
Introducing Enfamil Optimum, formerly known as Enfamil Enspire Optimum—now with a fresh new look but the same trusted nutrition for your little one.
Enfamil Optimum is designed to be our closest formula to breast milk, it has lactoferrin, a key protein found in colostrum and breast milk, and a dual HMO blend.
Perfect for combo feeding, Enfamil Optimum is ideal for supplementing breastfeeding, ensuring your baby gets essential nutrients while providing parents with convenience and peace of mind.
Enfamil Optimum has 2'FL & LnNT, two of the most abundant HMOs that are naturally present in breastmilk, to nourish their immune health.
With NO artificial growth hormones, NO artificial colors or flavors, and a NON-GMO* formula, Enfamil Optimum has complete nutrition for babies through 12 months. Give your baby the best start with Enfamil—trusted by parents†, backed by science.
*Added as an ingredient.
†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.
‡Among those who have a preference; based on the 2023 survey by AMC Global.
Available Formats and Sizes
Enfamil Optimum Infant Formula is available in powder form in tubs of 20.5 oz and 27.4 oz for your convenience and 30 oz refill boxes with 100% recycled paperboard to help us reduce environmental impact. You can also get Enfamil Optimum Infant Formula in cases of 4.
nutrients
vitamins
minerals
Please refer to your product packaging for the most accurate information.
Last Updated: 1/21/25
Your baby's health depends on carefully following the instructions below. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by your baby's doctor. Ask your baby's doctor which formula is appropriate for your baby. Ask your baby's doctor about the need to use cooled, boiled water for mixing and the need to boil clean utensils, bottles and nipples in water before use.
Wash hands thoroughly with soap & water before preparing formula.
Pour desired amount of water into the bottle. Add powder.
Cap bottle and SHAKE WELL.
Use the chart below for correct amounts of water and powder. Use scoop in carton to measure powder. Store DRY scoop in lid holder of the tub.
| To Make* | Water | Powder |
|---|---|---|
| 2 fl oz bottle | 2 fl oz | 1 unpacked level scoop (8.8 g) |
| 4 fl oz bottle | 4 fl oz | 2 unpacked level scoops (17.6 g) |
| 8 fl oz bottle | 8 fl oz | 4 unpacked level scoops (35.2 g) |
*Each scoop adds about 0.2 fl oz to the amount of prepared formula.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours.
Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.
Storage/Handling: Store powder at room temperature; avoid extreme temperatures. Refill pouches should only be used with reusable Enfamil Optimum tubs, sold separately. After opening, keep pouch and tub lid tightly closed, store in a dry area, and use contents within 1 month.
Use tub with Enfamil Optimum formula only. Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth.
Place new refill pouch inside the tub and keep the powder in the pouch.
Always refer to the batch code and "use by" date on the refill pouch.
USE BY DATE ON BOTTOM OF CARTON OR REFILL POUCH
Last updated: 8/19/25